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When lapsed Jew and former cardiologist Harry (James Caan) suddenly decides to spend his retirement as a pig farmer in Nazareth, Israel, the move deeply shocks his family and his new neighbours. Back in New York, Harry’s ex-wife Monica (Rosanna Arquette) is trying to manage the lives of their adult children, Annabelle and David (Jonathan Rhys Meyers), as well as her own.